Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.
- Cui Li, Dan Xu, Zhiheng Xu
- Biology, MedicineCell Stem Cell
- 7 July 2016
Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.
- Cui Li, Dan Xu, Zhiheng Xu
- BiologyCell Stem Cell
- 3 November 2016
Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins.
- Ki-Jun Yoon, G. Song, G. Ming
- BiologyCell Stem Cell
- 7 September 2017
Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex.
- Dan Xu, Feng Zhang, Yaqing Wang, Yiming Sun, Zhiheng Xu
- BiologyCell Reports
- 16 January 2014
Microcephaly-Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the Developing Neocortex.
- Dan Xu, Feng Zhang, Yaqing Wang, Yiming Sun, Zhiheng Xu
- BiologyCell Reports
- 2014
Update on the Animal Models and Underlying Mechanisms for ZIKV-Induced Microcephaly.
- Dan Xu, Cui Li, C. Qin, Zhiheng Xu
- Medicine, BiologyAnnual Review of Virology
- 30 September 2019
The current understanding of the effects of ZikV on mammalian brain development in different developmental stages is summarized and the potential underlying mechanisms of ZIKV-induced CZS are discussed.
Disruption of glial cell development by Zika virus contributes to severe microcephalic newborn mice
- Cui Li, Qin Wang, Zhiheng Xu
- Biology, MedicineCell Discovery
- 31 July 2018
It is shown that ZikV infection of embryos at the later stage of development causes severe microcephaly after birth and a single intraperitoneal injection of pregnant mice with a human monoclonal neutralizing antibody provides full protection against ZIKV infection and its associated damages in the developing fetuses.
A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development*♦
- Feng Zhang, Jingwen Yu, Zhiheng Xu
- Biology, ChemistryJournal of Biological Chemistry
- 29 March 2016
It is suggested that unique JNK protein complexes are involved in the diversified biological and pathological functions during brain development and pathogenesis of diseases.
The Yin and Yang of Autosomal Recessive Primary Microcephaly Genes: Insights from Neurogenesis and Carcinogenesis
- Xiaokun Zhou, Yiqiang Zhi, Jurui Yu, Dan Xu
- BiologyInternational Journal of Molecular Sciences
- 1 March 2020
The roles of MCPH genes in Autosomal recessive primary microcephaly and carcinogenesis are summarized and the underlying mechanisms are explored to explore new, attractive approaches to targeting tumor cells that are resistant to the current therapies.
MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis
- Dan Xu, Minghui Yao, Zhiheng Xu
- BiologyPLoS Biology
- 1 December 2018
The findings demonstrate that the coordinated reciprocal and bidirectional regulation among MEKK3, FBW7, WDR62, and JNK1, is required for fine-tuned JNK signaling for the control of balanced NPC self-renewal and differentiation during cortical development.
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