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Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.
TLDR
This model provides evidence for a direct link between Zika virus infection and microcephaly, with potential for further exploration of the underlying mechanisms and management of ZIKV-related pathological effects during brain development.
Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.
TLDR
The dataset has now been submitted to the Genome Sequence Archive of the Beijing Institute of Genomics Data Center under the accession number PRJCA000267 and the online version of the paper has been modified to include an Accession Numbers section.
Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins.
TLDR
The results reveal pathogenic mechanisms underlying ZIKV infection in the developing mammalian brain by systematically introducing individual proteins encoded by ZikV into the embryonic mouse cortex.
Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex.
TLDR
It is found that WDR62 knockdown leads to premature differentiation of neural progenitor cells (NPCs) and provides an insight into the molecular mechanisms underlying MCPH pathogenesis.
Disruption of glial cell development by Zika virus contributes to severe microcephalic newborn mice
TLDR
It is shown that ZikV infection of embryos at the later stage of development causes severe microcephaly after birth and a single intraperitoneal injection of pregnant mice with a human monoclonal neutralizing antibody provides full protection against ZIKV infection and its associated damages in the developing fetuses.
A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development*♦
TLDR
It is suggested that unique JNK protein complexes are involved in the diversified biological and pathological functions during brain development and pathogenesis of diseases.
Fast super-resolution imaging technique and immediate early nanostructure capturing by a photo-convertible fluorescent protein.
TLDR
A new photo-convertible fluorescent protein (PCFP), pcStar, and quick single molecule-guided Bayesian localization microscopy (Quick-SIMBA) are developed, which extended the application of SMLM to imaging the immediate early nanostructures in Drosophila embryos and revealed a specific "parallel three-pillar" structure in the neuronal-glial cell junction.
Genetic analysis of West Nile virus isolates from US blood donors during 2002-2005.
TLDR
The establishment of a dominant genotype across US and the displacement and possible extinction of earlier progenitor genotypes appears to have resulted from the accumulation and fixation of 11 nucleotide mutations throughout the coding region of WNV genome.
MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis
TLDR
The findings demonstrate that the coordinated reciprocal and bidirectional regulation among MEKK3, FBW7, WDR62, and JNK1, is required for fine-tuned JNK signaling for the control of balanced NPC self-renewal and differentiation during cortical development.
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