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Significance Receptor-interacting protein-1 (RIP1) kinase and caspase-8 are important players in activation of apoptotic pathways. Here we show that RIP1, caspase-8, and RIP3 contribute to… Expand
Caspase-8 is a player in pyroptosis The activation of certain pattern-recognition receptors by pathogen-associated molecular patterns results in the formation of inflammasome complexes. Inflammasome… Expand
Many immunostimulants act as vaccine adjuvants via activation of the innate immune system, although in many cases it is unclear which specific molecules contribute to the stimulatory activity. QS-21… Expand
Central role of NLRP12 in resistance to Yersinia pestis producing a Y. pseudotuberculosis -like LPS