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Glucose and glucagon-like peptide-1 have been shown to activate extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase in beta cells. We examined the contributions of the small GTPases Rap and Ras and the serine–threonine kinases B-Raf and Raf-1 to the activation of these kinases in human islet cells. The expression of Rap, Ras, B-Raf and(More)
NF␬B is a critical transcription factor involved in modulating cellular responses to environmental injuries. Tyrosine 42 phosphorylation of I␬B␣ has been shown to mediate NF␬B activation following hypoxia/ reoxygenation (H/R) or pervanadate treatment. This pathway differs from the canonical proinflammatory pathways, which mediate NF␬B activation through(More)
NF kappa B is a critical transcription factor involved in modulating cellular responses to environmental injuries. Tyrosine 42 phosphorylation of I kappa B alpha has been shown to mediate NF kappa B activation following hypoxia/reoxygenation (H/R) or pervanadate treatment. This pathway differs from the canonical proinflammatory pathways, which mediate NF(More)
Differences in [3H]nitrendipine binding sites in brain regions and subcellular fractions from cortex have been investigated in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. At 4 weeks of age, [3H]nitrendipine receptor binding (Bmax) was increased in the hypothalamus and striatum of SHR but not WKY rats, whereas no changes were found in(More)
Acknowledgments The authors gratefully acknowledge the assistance received in preparing this report. We thank Wolf is greatly appreciated. The research presented in this report is the product of the collaborative efforts of a large research team. The Principal Investigators thank our colleagues for their many contributions. We also thank our families, With(More)
This paper presents the development of a system that will allow a visually-impaired person to safely operate a motor vehicle. Named the blind driver challenge, the purpose of the project is to improve the independence of the visually-impaired by allowing them to travel at their convenience. The system development is targeted to be deployed on Team Victor(More)
With the introduction of Wisconsin Works (W-2) in 1997, Wisconsin initiated a radically new approach to public assistance for low-income families. W-2 replaced Aid to Families with Dependent Children (AFDC), the program that had previously offered cash to low-income, primarily single-parent families. W-2 participants are placed into one of four tiers of a "(More)
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