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OBJECTIVES To compare the antimicrobial activity of tigecycline and doxycycline against multiple isolates of Borrelia burgdorferi. METHODS In vitro antimicrobial assays were carried out using a microdilution assay. The time needed to inhibit, immobilize and kill the B31 strain of B. burgdorferi was determined. The MIC, MBC and concentration needed to(More)
The article investigated whether joint postures affect index finger muscle activation patterns. Ten subjects attempted to produce submaximal isometric forces in six orthogonal directions (palmar, dorsal, abduction, adduction, distal and proximal) at each of 9 different joint postures. Activation patterns were recorded from intramuscular electrodes inserted(More)
BACKGROUND Hemiparetic stroke survivors often exhibit profound weakness in the digits of the paretic hand, but the relative contribution of potential biomechanical and neurological impairment mechanisms is not known. Establishing sources of impairment would help in guiding treatment. OBJECTIVE The present study sought to quantify the role of diminished(More)
BACKGROUND Stroke survivors experience greater strength deficits during finger extension than finger flexion. Prior research indicates relatively little observed weakness is directly attributable to muscle atrophy. Changes in other muscle properties, however, may contribute to strength deficits. OBJECTIVES This study measured muscle fiber conduction(More)
An anatomically realistic biomechanical model of the index finger was created using a force-based approach in order to predict the isometric fingertip force or dynamic movement based on the forces of 7 index finger musculotendons. The model was validated for static forces through comparison with experimental results from 5 cadaver specimens. The model(More)