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Anti-malarial drug resistance is a primary public health problem. Haplotypes of pfcrt gene have been implicated to be molecular markers of chloroquine (CQ) resistance. This study aims to explore the prevalence of polymorphisms in pfcrt in Plasmodium falciparum-infected patients imported from Africa in Henan province. Blood samples were collected from 502(More)
PURPOSE To investigate Toll-like receptor (TLR) expression and reactivity in patients with the wet form age-related macular degeneration (AMD). METHODS Blood samples were collected from 25 patients with wet AMD and 25 age-matched healthy controls. Peripheral blood mononuclear cells (PBMCs) were isolated with Ficoll-Hypaque density gradient centrifugation.(More)
OBJECTIVE To compare the laboratory tests of the imported Plasmodium ovale infection and analyse the genetic character. METHODS After Giemsa staining and microscopy, CareStart rapid detection and nested PCR were used to detect two cases with P. ovale infection returning from Congo (Brazzaville) in Henan Province. Sequencing was performed after PCR(More)
OBJECTIVE To investigate the sensitivity of Anopheles sinensis to DDT, cyfluthrin, malathion and deltamethrin. METHODS In June 2009, 417, 421 and 433 mosquitoes were respectively captured from the fields of Tongbai county, Huaibin county, Yongcheng city, and tested by the adult Anopheles filter contact method recommended by WHO. The KT50 and the mortality(More)
Vivax malaria was historically epidemic in Henan Province of China and Anopheles sinensis was the main vectors and poor farming communities bare the greatest burden of disease. Knockdown resistance in An. sinensis is one of the mechanisms of resistance against pyrethroids. In the present study, the frequency of mutations from An. sinensis was examined in(More)
Thirty-seven blood samples from Plasmodium vivax-infected patients were collected in Henan Province in 2011. The gene for circumsporozoite protein (PvCSP) was amplified by nested PCR. According to the epidemiological data, among the 37 Plasmodium vivax malaria cases, 26 were indigenous cases and 11 were imported cases. A fragment of 750 bp was obtained in(More)
OBJECTIVE To analyze the epidemiological characteristics of malaria in Henan Province, and provide the basis for adjusting and formulating measures of malaria elimination timely. METHODS The data of malaria cases during 2005 and 2013 in Henan Province was collected and analyzed using Microsoft Office Excel 2003 and SPSS14.0. RESULTS Henan Province(More)
Giemsa-stained blood film microscopy, CareStart rapid detection and PCR were used to detect the three cases who returned from Angola and Equatorial Guinea to Henan Province. Onset of malaria symptoms for two patients occurred 15 d and 27 d after their return from Angola, respectively. Two months after returning home, another case relapsed who had suffered(More)
OBJECTIVE To study allergens and their relationship to the occurrence of childhood bronchial asthma in the Jiading District of Shanghai. METHODS Three hundred and eighty-two 4 to 12-year-old children with asthma in the remission stage from Nanxiang Hospital in the Jiading District of Shanghai were used as a case group (asthma group), and 402 children from(More)
A vivax malaria case in Henan Province was diagnosed as an indigenous case firstly in June 2013, and replased in April 2014. The clinical data of this case were collected and the epidemiological investigation was conducted. The blood samples were examined by Giemsa-stained blood smear, rapid diagnostic test strip (RDT) and nested PCR. This patient stayed at(More)