Dan Pinkel

Sort by:

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.

Richard M. Neve, Koei Chin, +24 authors Joe W. Gray
Cancer cell
2006

Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies when deregulated by genomic or epigenomic events. Here, we describe a model "system" to appraise the… (More)

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies.

Koei Chin, Sandy Devries, +21 authors Joe W. Gray
Cancer cell
2006

This study explores the roles of genome copy number abnormalities (CNAs) in breast cancer pathophysiology by identifying associations between recurrent CNAs, gene expression, and clinical outcome in… (More)

Somatic activation of KIT in distinct subtypes of melanoma.

John A. Curtin, Klaus J. Busam, Dan Pinkel, Boris C. Bastian
Journal of clinical oncology : official journal…
2006

PURPOSE Melanomas on mucosal membranes, acral skin (soles, palms, and nail bed), and skin with chronic sun-induced damage have infrequent mutations in BRAF and NRAS, genes within the… (More)

Hidden Markov models approach to the analysis of array CGH data

Jane Fridlyand, Antoine Snijders, Dan Pinkel, Donna Albertson, Ajay N. Jain
2004

The development of solid tumors is associated with acquisition of complex genetic alterations, indicating that failures in the mechanisms that maintain the integrity of the genome contribute to tumor… (More)

The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis

Mark D. Sternlicht, André Lochter, +6 authors Zena Werb
Cell
1999

Matrix metalloproteinases (MMPs) are invariably upregulated in the stromal compartment of epithelial cancers and appear to promote invasion and metastasis. Here we report that phenotypically normal… (More)

Breast tumor copy number aberration phenotypes and genomic instability

Jane Fridlyand, Antoine M. Snijders, +16 authors Donna Albertson
BMC Cancer
2006

Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability… (More)

Determinants of BRAF mutations in primary melanomas.

Janet L Maldonado, Jane Fridlyand, +7 authors Boris C. Bastian
Journal of the National Cancer Institute
2003

The RAS/mitogen-activated protein kinase pathway sends external growth-promoting signals to the nucleus. BRAF, a critical serine/threonine kinase in this pathway, is frequently activated by somatic… (More)

Rapid translocation frequency analysis in humans decades after exposure to ionizing radiation.

J. N. Lucas, Aziz Awa, +7 authors Joe Gray
International journal of radiation biology
1992

This paper presents an analysis of the utility of fluorescence in situ hybridization (FISH) with whole-chromosome probes for measurement of the genomic frequency of translocations found in the… (More)

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.

Lawrence A. Donehower, L A Godley, +7 authors H. E. Varmus
Genes & development
1995

By crossing mice that carry a null allele of p53 with transgenic mice that develop mammary adenocarcinomas under the influence of a Wnt-1 transgene, we have studied the consequences of p53 deficiency… (More)

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation.

Sundaresan Venkatachalam, Ya Ping Shi, +4 authors Lawrence A. Donehower
The EMBO journal
1998

Tumor suppressor genes are generally viewed as being recessive at the cellular level, so that mutation or loss of both tumor suppressor alleles is a prerequisite for tumor formation. The tumor… (More)

Filter Results:

Publication Year

Publication Type

Co-author

Journals and Conferences