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(1) A combination of penicillin and immune plasma protein has been obtained which possesses bacteriostatic activity. (2) The presence of the penicillinase immune plasma protein in this mixture protects penicillin in vitro from destruction by penicillinase.
Oral administration of penicillin suspended in equal parts of corn oil and lanolin extends the maintenance of the penicillin level in the system (as determined by urine bio-assay). Measurable quantities were found 24 to 42 hours after ingestion. Recovery of the penicillin is about five times higher than under administration in saline solution. We wish to… (More)
(1) Standardization of penicillinase has been made possible by the method for its assay. (2) A purified, dried and sterile penicillinase has been found to be a penicillin-inactivator superior to Clarase for the penicillin sterility test. (3) Preliminary studies show this penicillinase preparation may be used for inactivating penicillin in exudates of body… (More)
Observations made on animals subjected to parenteral administration of penicillin, at relatively high levels, disclosed a pseudo-positive albumin reaction. While it is not known if similar reactions have been noted after clinical treatment, there is at least a possibility that in cases where unusually high penicillin dosages are administered similar… (More)