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CD8 T cells exert their antiviral function through cytokines and lysis of infected cells. Because hepatocytes are susceptible to noncytolytic mechanisms of viral clearance, CD8 T-cell antiviral efficiency against hepatotropic viruses has been linked to their capacity to produce gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha). On the(More)
A distributed, parallel implementation of the widely-used Modular Semi-Automated Forces (ModSAF) Distributed Interactive Simulation (DIS) is presented, with Scalable Parallel Processors (SPPs) used to simulate more than 50,000 individual vehicles. The single-SPP code is portable and has been used on a variety of different SPP architectures for simulations(More)
The use of GPUs to accelerate the factoring of large sparse symmetric indefinite matrices shows the potential of yielding important benefits to a large group of widely used applications. This paper examines how a multifrontal sparse solver performs when exploiting both the GPU and its multi-core host. It demonstrates that the GPU can dramatically accelerate(More)
For many finite element problems, when represented as sparse matrices, iterative solvers are found to be unreliable because they can impose computational bottlenecks. Early pioneering work by Duff et al, explored an alternative strategy called multifrontal sparse matrix factorization. This approach , by representing the sparse problem as a tree of dense(More)
This paper presents the case that education in the 21<sup>st</sup> Century can only measure up to national needs if technologies developed in the simulation community, further enhanced by the power of high performance computing, are harnessed to supplant traditional didactic instruction. The authors cite their professional experiences in simulation, high(More)
The Information Sciences Institute and Caltech are enabling USJFCOM and the Institute for Defense Analyses to conduct entity-level simulation experiments using hundreds of distributed computer nodes on Linux Clusters as a vehicle for simulating millions of JSAF entities. Included below is the experience with the design and implementation of the code that(More)
This paper identifies, defines, and analyzes the limitations imposed on Modeling and Simulation by outmoded paradigms in computer utilization and data analysis. The authors then discuss two emerging capabilities to overcome these limitations: High Performance Parallel Computing and Advanced Data Analysis. First, parallel computing, in supercomputers and(More)
This paper addresses the use of emerging technologies to respond to the increasing needs for larger and more sophisticated agent-based simulations of urban areas. The U.S. Joint Forces Command has found it useful to seek out and apply technologies largely developed for academic research in the physical sciences. The use of these techniques in(More)