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Parallel Virtual Machine (PVM) is a widely-used software system that allows a heterogeneous set of parallel and serial UNIX-based computers to be programmed as a single message-passing parallel machine. In this paper, an extension to PVM to support dynamic process migration is presented. Support for migration is important in general-purpose workstation(More)
We are currently involved in research to enable PVM to take advantage of shared networks of workstations (NOWs) more eeectively. In such a computing environment , it is important to utilize workstations unobtrusively and recover from machine failures. Towards this goal, we have enhanced PVM with transparent task migration, checkpointing, and global(More)
Mercury and organomercurial resistance determined by genes on ten Pseudomonas aeruginosa plasmids and one Pseudomonas putida plasmid have been studied with regard to the range of substrates and the range of inducers. The plasmidless strains were sensitive to growth inhibition by Hg(2+) and did not volatilize Hg(0) from Hg(2+). A strain with plasmid RP1(More)
The novel anticancer compound T138067 is an irreversible inhibitor of tubulin polymerization. Amides 3-6 were synthesized using standard methodologies and determined to be significantly less lipophilic than T138067 based on logP calculations. Tubulin polymerization and [(3)H]-T138067 competition assays revealed that these amides are pro-drugs for parent(More)
The effects of exogenously applied oligodeoxynucleotides on Plasmodium falciparum proliferation was investigated. A fluorescence-activated cell sorter assay was employed to measure parasitemia after administration of either phosphodiester or phosphorothioate oligodeoxynucleotides. We report sequence-independent antimalarial activity preferentially with(More)
A novel series of pentafluorobenzenesulfonamides has been shown to inhibit the growth of a variety of human tumor cell lines. Among the cell types against which these agents were evaluated were the multidrug resistant (MDR) cell lines MCF-7/ADR and P388/ADR. The cytotoxic activity of members of this series of compounds was not affected by the multidrug(More)
The asexual erythrocytic stage of Plasmodium falciparum was grown in culture in the presence or absence of glycoconjugate polyanions of varying structure, size and substitutions. Heparin, dextran sulfate, fucoidan and pentosan polysulfate had antimalarial IC50 values between one and 11 microg ml(-1). Constituent heparin disaccharides were ineffective(More)
Manganese is growth inhibitory for Escherichia coli. The manganese concentration required for inhibition is dependent upon the magnesium concentration of the medium. Mutants have been isolated which are partially resistant to manganese inhibition in both liquid and solid media. From conjugation experiments, the genetic locus for manganese-resistance, mng,(More)
In using a shared network of workstations for parallel processing, it is not only important to consider heterogeneity and differences in processing power between the workstations but also the dynamics of the system as a whole. In such a computing environment where the use of resources vary as other applications consume and release resources, intelligent(More)