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In this paper, we discuss some of the issues in obtaining high performance for block-structured adaptive mesh refinement software for partial differential equations in complex geometry using embedded boundary/volume-of-fluid methods. We present the design of an adaptive embedded boundary multigrid algorithm for elliptic problems. We show examples in which(More)
In this paper, we give an overview of a set of methods being developed for solving classical PDEs in irregular geometries, or in the presence of free boundaries. In this approach, the irregular geometry is represented on a rectangular grid by specifying the intersection of each grid cell with the region on one or the other side of the boundary. This leads(More)
The impact of assay variability on pharmacokinetic modeling was investigated. Simulated replications (150) of three "individuals" resulted in 450 data sets. A one-compartment model with first-order absorption was simulated. Random assay errors of 10, 20, or 30% were introduced and the ratio of absorption rate (Ka) to elimination rate (Ke) constants was 2,(More)
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