Dan G. Pavel

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A simple and rapid procedure for in vivo labeling of red blood cells (RBC) is presented. The labeling is done with two consecutive intravenous injections, first of "cold" stannous pyrophosphate (Sn-PYP) and then of 99mTc-pertechnetate. Experimentally, a lag time of 30 min between the two injections was found to result in a mean RBC labeling of greater than(More)
125I-labeled monoclonal antibody 19-24 (mouse isotype IgG1) was evaluated for its potential usefulness in the clinical radioimmunodetection of sarcoma. The antibody reacts with a cell surface antigen preferentially expressed in many human soft tissue and bone sarcomas. Chromatographic and electrophoretic analyses indicated that the labeled preparation was(More)
UNLABELLED We conducted a prospective, randomized study comparing transcatheter partial splenic embolization (PSE) with splenectomy (SX) in 53 renal transplant candidates. An additional 112 PSE procedures were performed for various indications in 101 patients. STUDY RESULTS A mean +/- SD of 65% +/- 16% of splenic mass was ablated in the PSE group. The(More)
A noninvasive method for measurement of the individual kidney filtration fraction (FF) is presented, based on an analysis of the early rise of the kidneys' time-activity curves obtained after simultaneous injection of tubular [131I] ortho-iodohippurate and glomerular (Tc-99m DTPA) tracers. The analysis is based on the assumption that an insignificant amount(More)
Equilibrium gated radionuclide angiography was performed in 2 control groups (15 patients with no organic heart disease and 24 patients with organic heart disease but without right- or left-sided valvular regurgitation) and in 9 patients with clinical tricuspid regurgitation. The regurgitant index, or ratio of left to right ventricular stroke counts, was(More)
Functional imaging of the brain can aid in the diagnosis of Alzheimer's disease. Tc-HMPAO SPECT is widely available and relatively inexpensive to use. Combined with computer-based analysis of images, SPECT is a powerful tool in detecting decreases in brain perfusion caused by AIzheimer's disease. However, analysis can falsely elevate the perfusion of normal(More)
Persistence of impaired ventricular function after repair of cyanotic congenital heart defects may be due to previous exposure to chronic hypoxemia or to perioperative ischemic injury. Clarification of this phenomenon was sought in a canine model of cyanotic cardiovascular disease (Group I), in which the left atrium was anastomosed proximal to the banded(More)
The radionuclide regurgitant index, defined as left ventricular/right ventricular stroke counts obtained from gated equilibrium studies, has been reported to predict the presence and severity of left-sided valve regurgitation. This study evaluated the radionuclide regurgitant index in 100 patients in whom left-sided valve regurgitation was angiographically(More)