Dan A Waxman

Learn More
BACKGROUND There is little information in the medical literature on t he clinical spectrum of blood donation-related neurologic needle injury and on its frequency in a blood donor population. STUDY DESIGN AND METHODS Sixty-six cases of blood donation-related neurologic needle injury were identified from nursing reports made during a 2-year collection(More)
The safety of the blood supply depends on measures to protect not only the transfusion recipient but also the blood donor. Donor selection criteria have been voluntarily adopted or enforced through regulation in different countries, but review of practices in different blood centers reveals wide disparity in the current approaches. Such variability in(More)
  • Dan A Waxman
  • Therapeutic apheresis and dialysis : official…
  • 2004
Multicomponent donor apheresis utilizes apheresis technology to collect combinations of red blood cells, platelets and plasma units. The United States has embraced this technology to the greatest extent of the countries in the Americas. As whole blood and apheresis collection have increased, so have the donor deferrals based on potential exposure to(More)
This paper reviews the application of tranexamic acid, an antifibrinolytic, to trauma. CRASH-2, a large randomized controlled trial, was the first to show a reduction in mortality and recommend tranexamic acid use in bleeding trauma patients. However, this paper was not without controversy. Its patient recruitment, methodology, and conductance in(More)
BACKGROUND Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated death in the United States. Its diagnosis is based on clinical and radiographic changes that are indistinguishable from acute lung injury/acute respiratory distress syndrome (ALI/ARDS). TRALI is presumed to be a form of ALI/ARDS; however, it differs in(More)
The anti-tumor alkylating agent thio-TEPA is metabolized by hepatic cytochrome P450 to yield an oxo derivative. TEPA, plus one or more reactive metabolites. The contribution of this metabolism to the parent drug's cytotoxicity was evaluated in cell culture using the human breast carcinoma cell line MCF-7 as a model. Incubation of thio-TEPA in the presence(More)
Priapism is a dramatic, painful complication for some men afflicted by sickle cell anemia. Although the natural history remains unclear, many believe replacing the patient's abnormal red blood cells (RBCs) with normal RBCs by apheresis is effective. However, no controlled trials have demonstrated its effectiveness. We exchanged 7 men after medical(More)