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It is common practice in biochemical research to assume that iron bound to desferrioxamine (DFO) to form ferrioxamine (FOA) has been rendered inactive to subsequent redox chemistry within the range of physiological redox potentials, both in vitro and in vivo. However, plants and microorganisms can make iron metabolically available from ferrioxamine and(More)
The feasibility of using desferrioxamine (DF), an iron chelator, as a therapeutic agent against paraquat (PQ++) toxicity in male Sprague-Dawley rats was explored, based on the rationale of limiting toxic hydroxyl radical production from hydrogen peroxide by removing redox-active iron. Body weights, mortality, and lung histopathology were followed for(More)
Two-electron oxidation of cobaltous octaethylporphyrin [Co(II)(Et)(8)P] yields a stable pi-cation radical [Co(III)(Et)(8)P](2+.), the optical spectrum of which exhibits spectral changes dependent upon the nature of the counterion. Comparison of these spectra with those of Compounds I of horseradish peroxidase and catalase leads us to propose that these(More)
Chlorophyll a undergoes reversible one-electron oxidation in dichloromethane and butyronitrile. Removal of the electron by controlled potential electrolysis or by stoichiometric charge transfer to a known cation radical yields a radical (epr line width = 9 gauss, g = 2.0025 +/- 0.0001) whose optical spectrum is bleached relative to that of chlorophyll. Upon(More)
Studies documenting spin trapping of lipid radicals in defined model systems have shown some surprising solvent effects with the spin trap DMPO. In aqueous reactions comparing the reduction of H2O2 and methyl linoleate hydroperoxide (MLOOH) by Fe2+, hydroxyl (HO.) and lipid alkoxyl (LO.) radicals produce identical four-line spectra with line intensities(More)
Metal catalysis of membrane lipid oxidation has been thought to occur only at cell surfaces. However, conflicting observations of the pro-oxidant activity of ferric (Fe3+) vs ferrous (Fe2+) forms of various chelates have raised questions regarding this dogma. This paper suggests that the solubilities of iron complexes in lipid phases and the corresponding(More)