Damien Nicolas

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Fluorescence and bioluminescence time-lapse imaging allows to investigate a vast range of cellular processes at single-cell or even subcellular resolution. In particular, time-lapse imaging can provide uniquely detailed information on the fine kinetics of transcription, as well as on biological oscillations such as the circadian and cell cycles. However, we(More)
Mammalian transcription occurs stochastically in short bursts interspersed by silent intervals showing a refractory period. However, the underlying processes and consequences on fluctuations in gene products are poorly understood. Here, we use single allele time-lapse recordings in mouse cells to identify minimal models of promoter cycles, which inform on(More)
The Service scenarios have a crucial role in the overall functionality of Information Systems (IS). They should be treated and examined very carefully in order to fulfill the end-user expectations and the overall platform behavior by itself. To have a qualitative scenarios it is not enough to treat only the user expectation but also these scenarios should(More)
HL7 is a standard developed to support the exchange of information related to the medical field across institutions from the same country or from different countries. This standard provides mainly a framework to sustain the data exchange at the application / technical layer and the thereby minimize the importance of business / organization information. This(More)
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