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  • Gaël Cristofari, Damien Ficheux, J. L. Darlix
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2000 (First Publication: 23 June 2000)
  • The reverse transcription process for retroviruses and retrotransposons takes place in a nucleocore structure in the virus or virus-like particle. In retroviruses the major protein of the nucleocoreContinue Reading
  • Serena Bernacchi, Stoyl P. Stoylov, +4 authors Yves Mély
  • Chemistry, Biology, Medicine
  • Journal of molecular biology
  • 2002 (First Publication: 1 March 2002)
  • The nucleocapsid protein NCp7 of HIV-1 possesses a nucleic acid chaperone activity that is critical in minus and plus strand transfer during reverse transcription. The minus strand transfer notablyContinue Reading
  • Hervé Beltz, Jp Azoulay, +5 authors Yves Mély
  • Biology, Medicine
  • Journal of molecular biology
  • 2003 (First Publication: 1 April 2003)
  • Reverse transcription of HIV-1 genomic RNA to double-stranded DNA by reverse transcriptase (RT) is a critical step in HIV-1 replication. This process relies on two viral proteins, the RT enzyme andContinue Reading
  • Hervé Beltz, Céline Clauss, +7 authors Yves Mély
  • Biology, Medicine
  • Journal of molecular biology
  • 2005 (First Publication: 1 May 2005)
  • The nucleocapsid protein (NC) of human immunodeficiency virus type 1 (HIV-1) is formed of two highly conserved CCHC zinc fingers flanked by small basic domains. NC is required for the two obligatoryContinue Reading
  • Hugues de Rocquigny, Damien Ficheux, Caroline Gabus, Marie Claude Fournié-Zaluski, J. L. Darlix, Bernard Pierre Roques
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 1991 (First Publication: 1 October 1991)
  • The nucleocapsid protein (NC) of the human immunodeficiency virus type 1 plays a crucial role in the formation of infectious viral particles and therefore should be a major target for the developmentContinue Reading
  • Julien Godet, Hugues de Rocquigny, +4 authors Yves Mély
  • Biology, Medicine
  • Journal of molecular biology
  • 2006 (First Publication: 1 March 2006)
  • Reverse transcription of HIV-1 genomic RNA requires two obligatory strand transfers. During the first strand transfer reaction, the minus strand strong-stop DNA (ss-cDNA) is transferred byContinue Reading
  • A Mcalinden, Thomasin Ann Smith, Linda j. Sandell, Damien Ficheux, David A. D. Parry, David J S Hulmes
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2003 (First Publication: 24 October 2003)
  • Alpha-helical coiled-coils are widely occurring protein oligomerization motifs. Here we show that most members of the collagen superfamily contain short, repeating heptad sequences typical of coiledContinue Reading