Damian P. Redfearn

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OBJECTIVES We hypothesized an ablation strategy directly targeting muscle bundles might demonstrate functionally distinct "routes" of conduction, potentially shortening ablation times. BACKGROUND Pathological study demonstrated that the cavotricuspid isthmus is composed of distinct anatomically defined bundles, many with intervening gaps of connective(More)
The era of gene discovery and molecular medicine has had a significant impact on clinical practice. Knowledge of specific genetic findings causative for or associated with human disease may enhance diagnostic accuracy and influence treatment decisions. In cardiovascular disease, gene discovery for inherited arrhythmia syndromes has advanced most rapidly.(More)
Acquired long QT interval has been widely reported to be a consequence of drug therapy and electrolyte disturbances. We describe two cases of multifactorial acquired QT interval prolongation and torsades de pointes. In the first case, the drugs venlafaxine, amiodarone and domperidone may have contributed to QT interval prolongation in a patient with(More)
Pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (PAF) is successful in ∼70–80 % after repeated procedures. This suggests a subgroup of PAF patients where electrical abnormalities outside the pulmonary veins are important. Prolonged P-wave duration (PWD), a marker of atrial remodelling, may identify this subgroup. This study’s aim was to(More)
BACKGROUND Acquired long QT (LQT) interval is thought to be a consequence of drug therapy and electrolyte disturbances. HYPOTHESIS We characterize the potential effects of polypharmacy in a case series of acquired LQT and torsades de pointes (TdP) in order to determine whether multiple risk factors play a role in the development of LQT. METHODS The case(More)
AIMS Sleep apnoea (SA) is a common problem among congestive heart failure (CHF) patients. Evidence has shown that cardiac resynchronization therapy (CRT) reduces morbidity and mortality associated with CHF. The aim of this paper was to review studies evaluating the reduction of the Apnoea-Hypopnoea Index (AHI) in patients with SA after treatment with CRT(More)
AIMS The architecture of the cavotricuspid isthmus has been shown to be highly variable made of a large number of interspersed bundles in the majority. Targeting high-amplitude signals has resulted in short-ablation times, likely due to the selective ablation of such bundles. We report a series of cases where a single site ablation resulted in bidirectional(More)
BACKGROUND During pacemaker lead (PPML) implantation, the implanter must assess lead stability (fixation) and pacing threshold adequacy. Implanters rely principally on lead impedance (IMP) and pacing threshold measurements after fixation of the PPML to determine adequacy of pacing sites. Continuously monitoring lead parameters during fixation might better(More)
AIMS Sleep apnoea (SA) is a common breathing disorder that affects 5% of the North American adult population. It has been suggested that suppressing periods of bradycardia associated with apnoea may reduce the autonomic imbalance associated with SA, thereby improving the respiratory condition. The goals of this study were to conduct a systematic review to(More)
BACKGROUND Detailed analysis of signal-averaged P waves (SAPW) can provide insights into atrial electrophysiology. Abbreviated dosing of verapamil prior to cardioversion improves outcome at 1 week postcardioversion. The mechanism by which verapamil manifests benefit is uncertain. We hypothesized the SAPW would reflect any change in atrial electrophysiologic(More)