Damian Dudka

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Chromosome alignment in the middle of the bipolar spindle is a hallmark of metazoan cell divisions. When we offset the metaphase plate position by creating an asymmetric centriole distribution on each pole, we find that metaphase plates relocate to the middle of the spindle before anaphase. The spindle assembly checkpoint enables this centering mechanism by(More)
During mitosis cells can divide symmetrically to proliferate or asymmetrically to generate tissue diversity. While the mechanisms that ensure asymmetric cell division have been extensively studied, it is often assumed that a symmetric cell division is the default outcome of mitosis. Recent studies, however, imply that the symmetric nature of cell division(More)
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