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Epidermal growth factor receptor (EGFR) is a cell surface molecule and member of the ErbB family of receptor tyrosine kinases. Its activation leads to proliferation, antiapoptosis, and metastatic spread, making inhibition of this pathway a compelling target. In recent years, an increasing number of clinical trials in the management of solid malignancies(More)
Dear Editor, A 49-year-old Turkish male presented with intermittent passage of dark-colored urine since 2007. Flow cytometry demonstrated absence of CD55 and CD59 antigens, consistent with a diagnosis of paroxysmal nocturnal hemoglobinuria (PNH). He initially responded to eculizumab, with improvement in anemia and resolution of hemoglobinuria. In 2009, the(More)
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