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The paper develops innovative methodology for robust and stable design of digital infinite impulse response (IIR) filters using a heuristic search method. The proposed heuristic search method enhances the capability to explore and exploit the search space locally as well globally to obtain optimal filter design parameters. A multicriterion optimization is(More)
In our previous study, the saponin-rich fraction (SRF) of adventitious root extract of Ficus religiosa L. (Moraceae) was shown to have an anticonvulsant effect in acute animal models of convulsions. The present study was envisaged to study the effect of SRF in the pentylenetetrazol (PTZ) kindling mouse model and its associated depression and cognition(More)
CONTEXT Ficus religiosa Linn (Moraceae) is a variety of fig tree. Its figs are known to contain a high serotonergic content, and modulation of serotonergic neurotransmission plays a crucial role in the pathogenesis of amnesia. Thus, the present study was envisaged. OBJECTIVE To investigate the effect of the methanol extract of figs of Ficus religiosa(More)
Oxidative stress, together with mitochondrial dysfunction, has been reported to be involved in the pathogenesis of epileptogenesis and its associated comorbidities. Phytoflavonoids have shown numerous beneficial ameliorative effects on different neurological disorders by virtue of their antioxidant effect. The present study investigated the effect of(More)
Analysis of Confocal Laser Scanning Microscopy (CLSM) images is gaining popularity in developmental biology for understanding growth dynamics. The automated analysis of such images is highly desirable for efficiency and accuracy. The first step in this process is segmentation and tracking leading to computation of cell lineages. In this paper, we present(More)
Automated segmentation and tracking of cells in actively developing tissues can provide high-throughput and quantitative spatiotemporal measurements of a range of cell behaviors; cell expansion and cell-division kinetics leading to a better understanding of the underlying dynamics of morphogenesis. Here, we have studied the problem of constructing cell(More)
In epileptic patients cyproheptadine is frequently prescribed as an appetite stimulant for the treatment of anorexia associated with anti-epileptic drugs and for the management of 'serotonin syndrome' in depressed epileptic patients. However, the study of serotonergic and histaminergic pathway shows that the decreased neurotransmission of serotonin and(More)
BACKGROUND Exploration of therapeutic mechanism is an integral part of medicinal plant based drug discovery for better understanding of pharmacological behavior of these agents. But, its study using conventional hit and trial wet laboratory experiments proves to be very tedious, time consuming and expensive, thus encouraging development of in silico(More)
In this paper an Enhanced Teaching-Learning Based Optimization (ETLBO) algorithm is employed to design stable digital infinite impulse response (IIR) filter using L p-norm error criterion. The original TLBO algorithm has been remodeled by merging the concept of opposition-based learning and migration for selection of good candidates and to maintain the(More)