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Hyaluronic acid family in bladder cancer: potential prognostic biomarkers and therapeutic targets
TLDR
This study demonstrates that the HA family can be exploited for developing a biomarker-driven, targeted treatment for bladder cancer, and 4MU, a non-toxic oral HA synthesis inhibitor, is one such candidate. Expand
Clinical parameters outperform molecular subtypes for predicting outcome in bladder cancer: Results from multiple cohorts including TCGA.
TLDR
Molecular subtypes reflect bladder tumor heterogeneity and associate with tumor-grade and in multiple cohorts/subtyping-classifications, clinical parameters outperform subtypes for predicting outcome. Expand
β-Arrestins Regulate Stem Cell-Like Phenotype and Response to Chemotherapy in Bladder Cancer
TLDR
This work shows for the first time that β-arrestins have prognostic significance for predicting metastasis and response to chemotherapy in bladder cancer and ARRBs regulate cancer stem cell-like properties in bladder cancers and are potential prognostic indicators for tumor progression and chemotherapy response. Expand
A chemokine/chemokine receptor signature potentially predicts clinical outcome in colorectal cancer patients.
TLDR
Results of 451 specimens from both cohorts reveal that the CXCR-4/7+CXCL-12 signature potentially predicts outcome in CRC patients and may allow earlier intervention. Expand
Molecular targeting of renal cell carcinoma by an oral combination
TLDR
This study highlights how targeting specific mechanisms that cause the failure of “old” modestly effective FDA-approved drugs could improve treatment response with minimal alteration in toxicity profile. Expand
Promotion of epithelial hyperplasia by interleukin‐8—CXCR axis in human prostate
TLDR
This work evaluated the expression of inflammatory cytokines in clinical specimens, primary cultures, and prostatic lineage cell lines to investigate whether IL‐8 via its receptor system (IL‐8 axis) promotes BPH. Expand
The Effect of Bupivacaine on the Efficacy of Antibiotic Coating on Penile Implants in Preventing Infection
TLDR
The addition of BUP does not impede the in vitro antibacterial activity of InhibiZone-coated AMS or R+G-soaked Coloplast and can potentially be used during penile prosthesis surgery pending clinical trials. Expand
RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal
TLDR
Genetic and biochemical evidences are provided that RAD51AP1 is critical for tumor growth and metastasis by increasing BCSC self-renewal and may serve as a novel target for chemotherapy- and radiotherapy-resistant breast cancer. Expand
A Novel Splice Variant of HYAL-4 Drives Malignant Transformation and Predicts Outcome in Patients with Bladder Cancer
TLDR
This study discovered the first naturally-occurring eukaryotic/human Chase and connected it to disease pathology, specifically cancer. Expand
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