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S100/calgranulin polypeptides are present at sites of inflammation, likely released by inflammatory cells targeted to such loci by a range of environmental cues. We report here that receptor for AGE (RAGE) is a central cell surface receptor for EN-RAGE (extracellular newly identified RAGE-binding protein) and related members of the S100/calgranulin(More)
BACKGROUND Eukaryotic cells localize selected mRNAs to a region of the cell as a means to sequester proteins. Signals within the 3' untranslated region (3' UTR) facilitate mRNA localization by both actin and microtubule cytoskeletal systems. Recently, an mRNA in the yeast Saccharomyces cerevisiae, ASH1, was shown to coalesce into a discrete particle that is(More)
  • Jacalyn Vogel, Ben Drapkin, Jamina Oomen, Dale Beach, Kerry Bloom, Michael Snyder
  • 2001
sis, has simple microtubule arrays with discrete functions during the cell cycle yeast MTOC, the spindle pole body (SPB), are conserved with other eukaryotes (Murphy et al., 1998; Tassin et al., Summary Many temperature-sensitive tub4 mutants fail to form microtubules (Marschall et al., 1996), suggesting that ␥-Tubulin is essential for microtubule(More)
BACKGROUND Two genetic 'pathways' contribute to the fidelity of nuclear segregation during the process of budding in the yeast Saccharomyces cerevisiae. An early pathway, involving Kar9p and other proteins, orients the mitotic spindle along the mother-bud axis. Upon the onset of anaphase, cytoplasmic dynein provides the motive force for nuclear movement(More)
There is widespread agreement that science, technology, engineering, and mathematics programs should provide undergraduates with research experience. Practical issues and limited resources, however, make this a challenge. We have developed a bioinformatics project that provides a course-based research experience for students at a diverse group of schools(More)
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