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CONTEXT Clinical studies of omega-3 polyunsaturated fatty acids (PUFAs) have shown a reduction in sudden cardiac death, suggesting that omega-3 PUFAs may have antiarrhythmic effects. OBJECTIVE To determine whether omega-3 PUFAs have beneficial antiarrhythmic effects in patients with a history of sustained ventricular tachycardia (VT) or ventricular(More)
OBJECTIVE To determine the effect of yoga and of aerobic exercise on cognitive function, fatigue, mood, and quality of life in multiple sclerosis (MS). METHODS Subjects with clinically definite MS and Expanded Disability Status Score less than or equal to 6.0 were randomly assigned to one of three groups lasting 6 months: weekly Iyengar yoga class along(More)
BACKGROUND To assess capacity for colonoscopy, we need to understand current utilization of colonoscopy in diverse clinical practice settings. The objective of this study was to determine the utilization of colonoscopy in diverse clinical practice settings. METHODS The Clinical Outcomes Research Initiative (CORI) data repository, which receives endoscopy(More)
BACKGROUND Physician-assisted suicide was legalized in Oregon in October 1997. There are data on patients who have received prescriptions for lethal medications and died after taking the medications. There is little information, however, on physicians' experiences with requests for assistance with suicide. METHODS Between February and August 1999, we(More)
PURPOSE To compare gadoteridol and ferumoxytol for measurement of relative cerebral blood volume (rCBV) in patients with glioblastoma multiforme (GBM) who showed progressive disease at conventional magnetic resonance (MR) imaging after chemo- and radiation therapy (hereafter, chemoradiotherapy) and to correlate rCBV with survival. MATERIALS AND METHODS(More)
CONTEXT There are potential benefits of mind-body techniques on cognitive function because the techniques involve an active attentional or mindfulness component, but this has not been fully explored. OBJECTIVE To determine the effect of yoga on cognitive function, fatigue, mood, and quality of life in seniors. DESIGN Randomized, controlled trial(More)
The TREC 2004 Genomics Track consisted of two tasks. The first task was a standard ad hoc retrieval task using topics obtained from real biomedical research scientists and documents from a large subset of the MEDLINE bibliographic database. The second task focused on categorization of full-text documents, simulating the task of curators of the Mouse Genome(More)
OBJECTIVE To evaluate the effectiveness of Stanford's Chronic Disease Self-Management Program (CDSMP) for chronic low back pain (LBP) in older Americans. DESIGN Randomized controlled trial. SETTING Community-based program offered at 12 locations. SUBJECTS Community-dwelling seniors (n = 109) aged 60 and older with chronic LBP of mechanical origin. (More)
BACKGROUND The aim of this study was to determine the safety and efficacy of intraarterial chemotherapy with osmotic opening of the blood-brain barrier (BBB) for the treatment of malignant brain tumors when administered across multiple centers. METHODS Patients with primary central nervous system lymphoma (PCNSL), primitive neuroectodermal tumor (PNET),(More)
PURPOSE To describe the frequency and severity of ototoxicity in a series of pediatric patients treated with platinum-based chemotherapy. PATIENTS AND METHODS Serial audiologic evaluations were conducted for 67 patients aged 8 months to 23 years who received platinum-based chemotherapy. Audiologic data was analyzed to determine time to hearing-loss using(More)