Dale Boucher

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The oncogene GLI is amplified and expressed in some cases of human malignant glioma and undifferentiated childhood sarcoma and is the prototype for a gene family characterized by a highly conserved set of five tandem zinc fingers and a consensus cysteine-histidine link. This zinc finger motif has been shown to bind DNA with sequence specificity and may(More)
A transgenic mouse strain derived from embryonic stem (ES) cells infected with multiple copies of a retroviral vector carries a recessive insertional mutation resulting in prenatal lethality. A detailed histological analysis of developing embryos has shown that the mutation results in hyperplasia of both embryonic and extraembryonic ectoderm and failure of(More)
We present an "artificial neural tissue" (ANT) architecture as a control system for autonomous multirobot tasks. This architecture combines a typical neural-network structure with a coarse-coding strategy that permits specialized areas to develop in the tissue which in turn allows such emergent capabilities as task decomposition. Only a single global(More)
Automation of site preparation and resource utilization on the Moon with teams of autonomous robots holds considerable promise for establishing a lunar base. Such multirobot autonomous systems would require limited human support infrastructure, complement necessary manned operations and reduce overall mission risk. We present an Artificial Neural Tissue(More)
NASA's planned permanent return to the Moon by the year 2018 will demand advances in many technologies. Just as those pioneers who built a homestead in North America from abroad, it will be necessary to use the resources and materials available on the Moon, commonly referred to as in-situ resource utilization. This benefit would come in a number of ways.(More)
Automation of mining and resource utilization processes on the Moon with teams of autonomous robots holds considerable promise for establishing a lunar base. We present an Artificial Neural Tissue (ANT) architecture as a control system for autonomous multirobot tasks. An Artificial Neural Tissue (ANT) approach requires much less human supervision and(More)
In order to explore the protective function of human glutathione S-transferase pi (GST-pi) in vitro and in vivo, transfected NIH 3T3 clones were examined in cytotoxicity assays using the carcinogen (+/-)anti-benzo(a)pyrene 7,8-diol-9,10-epoxide (BPDE) or inoculated into nude mice and treated with the carcinogen benzo(a)pyrene (BP) to induce tumor formation.(More)
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