Dale A. Freeman

Publications58
h-index20
Citations1,281
Highly Influential Citations15
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Factors underlying the variability of lipid droplet fluorescence in MA-10 Leydig tumor cells.
Neutral lipids accumulate in cellular lipid droplets. These droplets vary remarkably in number and amount between cells. In the present studies, the variability in lipid content was quantified by… Expand
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Steroid hormone-producing tumors in man.
TUMORS derived from steroid hormone-producing cells of the adrenal, ovary, and testes are rare. The tumors are, however, important both as causes of disease entities and as useful model systems for… Expand
  • 59
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Varying susceptibility of different low density lipoproteins to oxidative modification.
The oxidative modification of low density lipoprotein (LDL) may provide a crucial link between plasma LDL and the atherosclerotic lesion. The studies presented herein define time-dependent… Expand
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Evaluation of six fluorescent protein stains for use in flow microfluorometry.
Flow microfluorometric (FMF) analysis of stained cells has provided protein distribution histograms for large populations of cells. Spectral data and staining protocols were evaluated for six… Expand
  • 34
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Plasma membrane cholesterol: removal and insertion into the membrane and utilization as substrate for steroidogenesis.
The plasma membrane cholesterol content of MA-10 Leydig tumor cells is depleted by trophic hormone stimulation and repleted by incubating the cells with low density lipoprotein. The present studies… Expand
  • 46
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Influence of nicotine, cotinine, anabasine and cigarette smoke extract on human granulosa cell progesterone and estradiol synthesis.
To reveal the well known effect of smoking on the incidence of early abortion, the possible effects of cigarette alkaloids on progesterone and estradiol synthesis were investigated. A suspected cause… Expand
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A cholesteryl ester hydrolase inhibitor blocks cholesterol translocation into the mitochondria of MA-10 Leydig tumor cells.
The present studies describe an unexpected action of a cholesteryl ester hydrolase inhibitor on MA-10 Leydig tumor cells. These studies were initially intended to use the inhibitor,… Expand
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Intracellular Cholesterol Trafficking
Regulation of ACAT and intracellular cholesterol level Niemann-Pick Type C disease cholesterol transport in specialized cells sterol carrier protein-2 and cholesterol transport proteins caveolae and… Expand
  • 26
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Desensitization to gonadotropins in cultured Leydig tumor cells involves loss of gonadotropin receptors and decreased capacity for steroidogenesis.
The ability of human choriogonadotropin (hCG) to regulate its receptors and target cell responses has been studied in a clonal strain of cultured Leydig tumor cells (MA-10). Exposure of the MA-10… Expand
  • 57
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Inhibition of Steroidogenesis in Cultured Leydig Tumor Cells by 22-Amino-23,24-Bisnor-5-Cholen-3β-Ol and (20R)20-Phenyl-5-Pregnene-3β,20-Diol
Using the cholesterol side-chain cleavage enzyme purified from bovine adrenals, we have previously shown that 22-amino-23,24-bisnor-5-cholen-3-α-ol (22-ABC) and (20R)20-phenyl-5-pregnene-3α,20 diol… Expand
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