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PURPOSE From the Hippocratic Oath to the World Medical Association's Declaration of Geneva, physicians have sworn to protect patients' privacy. However, as systems move to more integrated architectures, protecting this medical data becomes more of a challenge. The increase in complexity of IT environments, the aggregation of data, and the desire of other(More)
We present the design and implementation of VISAGE (VISual AGgregator and Explorer), a query interface for clinical research. We follow a user-centered development approach and incorporate visual, ontological, searchable and explorative features in three interrelated components: Query Builder, Query Manager and Query Explorer. The Query Explorer provides(More)
For the success of clinical and translational science, a seamless interoperation is required between clinical and research information technology. Addressing this need, the Michigan Clinical Research Collaboratory (MCRC) was created. The MCRC employed a standards-driven Web Services architecture to create the U-M Honest Broker, which enabled sharing of(More)
Clinicians and biomedical research investigators ordinarily use natural language when describing biomedical concepts and constructs, even in the context of highly structured case report forms. We describe work in progress and lessons learned in translating complex natural-language concepts on case report forms into machine-readable format using the HL7 CDA,(More)
To advise in the selection of a clinical trial management system (CTMS), we evaluated three candidate applications. After preliminary analyses,we performed heuristic evaluation and usability testing to assess system's usability. Velos eResearch,a commercial CTMS, had the best usability outcome despite having fewer features in comparison. In the decision(More)
Multiple clinical informatics systems have been developed within separate departments of the University of Michigan Medical School. We are in the process of creating an "Honest Broker" method of safely and securely linking together data from different clinical systems for a research project studying the co-morbidity of depression and cardiovascular disease.(More)
We face an awe-inspiring prospect in the 21st century   the unification of the fund of knowledge for the entire human species. This article reexamines the medieval Memory Palace concept, a powerful mnemonic device, and the surrealistic art of M. C. Escher to uncover design patterns for information architecture that will help us build XML-based tools for(More)
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