Daisy Tabuena

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Mutations that reduce the function of KCNQ2 channels cause neuronal hyperexcitability, manifested as epileptic seizures and myokymia. These channels are present in nodes of Ranvier in rat brain and nerve and have been proposed to mediate the slow nodal potassium current I(Ks). We have used immunocytochemistry, electrophysiology and pharmacology to test this(More)
Sir, X-linked dystonia–parkinsonism (XDP, DYT3, also referred to as “Lubag”) is a neurodegenerative disorder characterized by a unique combination of parkinsonism and dystonia [1]. The insertion of short interspersed nuclear element, variable number of tandem repeats, and Alu composite (SVA) retrotransposon has been identified in intron 32 of the(More)
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