Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify… (More)
Recent studies have highlighted the involvement of rare (<1% frequency) copy-number variations and point mutations in the genetic etiology of autism spectrum disorder (ASD); these variants… (More)
SHANK genes code for scaffold proteins located at the post-synaptic density of glutamatergic synapses. In neurons, SHANK2 and SHANK3 have a positive effect on the induction and maturation of… (More)
In this technical note we show the promise of using graphic processing units (GPUs) to accelerate simulations of electrical wave propagation in cardiac tissue, one of the more demanding computational… (More)
Autism is a common neurodevelopmental disorder with a complex mode of inheritance. It is one of the most highly heritable of the complex disorders, although the underlying genetic factors remain… (More)
While a photograph is a visual artifact, studies reveal that a number of people with visual impairments are also interested in being able to share their memories and experiences with their sighted… (More)
Smartphones and tablet devices have been rapidly proliferating, and multi-touch interaction, powerful processors and rich array of sensors make these devices an attractive service platform for older… (More)
There are billions of people who face problems in accessing webpages, including people with disabilities, elderly people, and illiterate people in developing countries. The needs for accessible… (More)
The three members of the human neurexin gene family, neurexin 1 (NRXN1), neurexin 2 (NRXN2), and neurexin 3 (NRXN3), encode neuronal adhesion proteins that have important roles in synapse development… (More)
Crowd accessibility services for people with disabilities, driven by crowd-sourcing methods, are gaining traction as a viable means of realizing innovative services by leveraging both human and… (More)