Daisuke Kitayama

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IgE plays an important role in the pathogenesis of allergic diseases and high-affinity IgE memory B cells are differentiated from IgG1 B cells developed in germinal centers. Bcl6, a sequence specific transcriptional repressor, is highly expressed in germinal center B cells and suppresses expression of Cvarepsilon germline transcript. However, a role for(More)
CXCR4 expression is critical for localization of centroblasts in the dark zone of germinal centers (GCs), and centrocytes downregulate CXCR4 and thus leave the dark zone to reside in the light zone. However, mechanisms governing CXCR4 downregulation on centrocytes are not known. In this study, we show that the amount of intracellular CXCR4 in centroblasts(More)
Although IL-4 and IL-21 synergistically promote proliferation and differentiation of activated B cells, the mutual role in their collaboration is not known. When splenic B cells were sequentially stimulated with anti-IgM Ab and anti-CD40 Ab plus IL-4 and then with IL-21 at a 2-day interval, proliferation, frequency of class switching to IgG1 and plasma cell(More)
We describe a 66-year-old man having hepatocellular carcinoma with tumor thrombus extending into the inferior vena cava and synchronous pulmonary metastasis. He was referred to Chiba University Hospital on May, 2000, complaining of emaciation. Radiological findings showed a huge hepatocellular carcinoma in the entire right lobe and tumor thrombus extended(More)
Although location-based information systems can now be accessed from mobile devices, searching for information from an outdoor environment requires a significant amount of effort given the time-consuming manipulations that need to be made. Augmented-Reality (AR) based systems can help resolve these issues by reducing the physical effort required to input(More)
In this paper, we propose a method of enhancing digital map interface by reflecting users' intentions by means of automatically restructured maps. Extracted from the sequences of the users' map operations (zooming, centering, and panning), the users' intentions determine the types of objectives based on the sequence patterns or the semantic relation between(More)
A method was developed to enable users of video sharing websites to easily retrieve video scenes relevant to their interests. The system analyzes both text and non-text aspects of a user’s comment and then retrieves and displays relevant scenes along with attached comments. The text analysis works in tandem with non-text features, namely, the selected area(More)
IL-21 has a pro-apoptotic effect on freshly isolated B cells stimulated with LPS, and also induces Bcl6 expression in the activated B cells. However, a role for Bcl6 in the activated B cells is not known. When naive B cells from Bcl6-deficient mice were stimulated with LPS plus IL-21, those B cells died by apoptosis as wild-type B cells. Co-stimulation of(More)