Daisuke Kano

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[reaction: see text] Pyrrolidines and bicyclic pyrrolidine derivatives can effectively be synthesized from gamma-iodoolefins using commercially available chloramine-T (CT) as a nitrogen source. The cyclization proceeds with high stereoselectivity via a cyclic iodonium intermediate.
In vivo biodistribution of small interfering RNAs (siRNAs) is important to develop them for medical use. Therefore, novel single photon emitter-labelled siRNA was prepared by using diethylenetriamine-N,N,N',N″,N″-pentaacetic acid (DTPA) and poly(A) polymerase, and subsequently, real-time analysis of siRNA trafficking was performed by using single photon(More)
The bone scan index (BSI) is calculated from a whole-body bone scan image; it shows the tumor burden in bone as a percentage of total skeletal mass. It has been used to determine the prognosis and to assess treatment effects; however, little has been reported on whether the BSI calculated using a two-dimensional image can accurately evaluate the(More)
Whereas Monte Carlo (MC) simulation is widely utilized in estimation of the scatter component, a simulation model which can calculate the scatter fraction (SF) of each patient is needed for making an accurate image quality assessment for clinical PET images based on the noise equivalent count. In this study, an MC simulation model was constructed which can(More)
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