Daisuke Hihara

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During mitosis, the spindle assembly checkpoint (SAC) inhibits the Cdc20-activated anaphase-promoting complex/cyclosome (APC/C(Cdc20)), which promotes protein degradation, and delays anaphase onset to ensure accurate chromosome segregation. However, the SAC function in meiotic anaphase regulation is poorly understood. Here, we examined the SAC function in(More)
Introduction Meiosis is a special type of cell division that generates haploid gametes from diploid progenitors. During meiosis, two rounds of chromosome segregation successively take place without an intervening S phase. At meiosis I (MI), homologues segregate apart from each other (reductional segregation), whereas at mei-osis II (MII), sister chromatids(More)
Ultrathin colonoscopes (UTC) reportedly produce less pain during colonoscopy than standard colonoscopes. The aim of this study was to assess the tolerability of an UTC compared with that of a pediatric colonoscope. A total of 270 adult patients scheduled to undergo colonoscopy were randomized, with 134 allocated to the UTC group and 136 to the pediatric(More)
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