Daisuke Asai

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Introduction • System should be applicable in routine microsurgery. • System should be maneuverable in the deep & narrow surgical field. • Relatively wide range of motion at the depth should be equipped. • Secure procedure need to be performed. To remove a tumor Forceps Normal brain tissue In the neurosurgery, • Surgeon has to perform a precise(More)
Genetic alterations of Ikaros family zinc finger protein 1 (IKZF1), point mutations in Janus kinase 2 (JAK2), and overexpression of cytokine receptor-like factor 2 (CRLF2) were recently reported to be associated with poor outcomes in pediatric B-cell precursor (BCP)-ALL. Herein, we conducted genetic analyses of IKZF1 deletion, point mutation of JAK2 exon(More)
Peptide substrates sensitive for a certain protein kinase could be important for new-drug development and to understand the mechanism of diseases. Rho-associated kinase (Rho-kinase/ROCK) is a serine/threonine kinase, and plays an important part in cardiovascular disease, migration and invasion of tumor cells, and in neurological disorders. The purpose of(More)
Recently, we have proposed a novel strategy for a cell-specific gene therapy system based on responses to intracellular signals. In this system, an intracellular signal that is specifically and abnormally activated in the diseased cells is used for the activation of transgene expression. In this study, we used protein kinase C (PKC)a as a trigger to(More)
Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF-MS) is frequently used to monitor phosphorylated peptides or protein kinase activities. However, few reports have compared a radioactivity assay with MALDI-TOF-MS analysis. We analyzed the phosphorylation ratios of 23 peptide substrates for G protein-coupled receptor(More)
We examine how the sharing of parents' medication compliance information with their mature children can support compliance. We develop a medication management system that reminds the parents to take their medication as well as informing their children of compliance status. We install the system into the homes of four families consisting of parents living(More)