Daijiro Higashi

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BACKGROUND To understand the molecular and morphological alterations in the tight junction in colorectal cancer (CRC) tissues, the expression of eight tight junction proteins in normal and cancer colorectal tissues were compared. PATIENTS AND METHODS Adenocarcinoma tissues and paired normal mucosa were resected from surgical specimens of CRC patients. The(More)
BACKGROUND Crohn's disease (CD) cases have been increasing and prolonged cases are now frequent. In addition, in Japan, more cases with concomitant malignant disease have also recently been reported. There is a particularly high risk of cancer occurring simultaneously in the lower rectum and the anal area. PATIENTS AND METHODS Two-hundred and eighty-six(More)
BACKGROUND Infliximab has played a central role in the treatment of luminal Crohn's disease (CD) due to its great usefulness. Although the seton placement has been widely used for the treatment of anal fistula in patients with CD, we have used infliximab for severe cases in which improvement was not achievable by the seton placement, or for patients in whom(More)
BACKGROUND Colorectal cancer that develops as a complication of ulcerative colitis (UC) is a serious problem that affects the patient's prognosis. Such cancer is characterized by development at an early age, a high incidence of multiple tumors, poorly differentiated carcinoma and mucinous carcinoma. Special attention should therefore be paid to the(More)
Due to an increase in the number of long-term cases of Crohn's disease, the risk of combined cancer in these patients has been assessed in numerous articles. Most of these reports have involved patients with cancer of the large intestine, while cases of cancer of the small intestine combined with Crohn's disease are very rare. We experienced two cases of(More)
BACKGROUND AND AIM There have been very few reported investigations on the standardized incidence ratio (SIR) of intestinal cancer and all cancers other than intestinal cancer with Crohn's disease (CD) by organ in Japan. This study examined the risk of developing cancer (i.e. SIR) that occurs in association with CD. METHODS The subjects were 770 CD(More)
BACKGROUND AND AIMS Intestinal complications of stenosis or fistula may occur during the course of Crohn's disease (CD), and surgery is performed in a fair number of patients. The risk factors for initial surgery in a Japanese hospital-based cohort of CD patients were evaluated. METHODS This study was a single-center, retrospective, cohort study. The(More)
BACKGROUND AND AIM   Ulcerative colitis (UC) is not only characterized by pathological lesions localized to colonic mucosa, but also to various complications involving other organs, including postoperative pouchitis. Among these complications, diffuse gastroduodenitis with lesions resembling colonic lesions has been reported, albeit rarely.The aim of the(More)
BACKGROUND Developed as a biological response modifier (BRM), lentinan mitigates patients' symptoms by boosting the immune system. In combination with S-1 (tegafur, gimeracil, oteracil), lentinan is reported to mitigate adverse reactions to therapy for unresectable recurrent gastric cancer and prolong survival. However, there are few reports from actual(More)
BACKGROUND Although rare, duodenal lesions have been reported in association with ulcerative colitis (UC); however, there have been very few reports on small bowel lesions, and many aspects of their pathology and frequency remain unknown. This study determined whether small bowel lesions are present in UC by using wireless capsule endoscopy (WCE). (More)