Daiichiro Tanaka

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Thalamostriatal projections from the ventral anterior nucleus (VA) were mapped by using autoradiographic and horseradish peroxidase techniques in the dog. Injections of tritiated leucine and proline into the lateral, central, and medial parts of VA resulted in anterograde label over the dorsolateral, midlateral, and dorsal parts of the head of the caudate(More)
This study compared the neurotoxic effects of triphenyl phosphite (TPP) in the rat with those seen after exposure to diisopropylphosphorofluoridate (DFP), a compound known to produce organophosphorus-induced delayed neurotoxicity (OPIDN). Animals received either three subcutaneous injections of TPP (1184 mg/kg body wt each dose) administered at 3-day(More)
The distribution and morphology of cholinergic and non-cholinergic neurons projecting to the caudal intralaminar thalamic nuclei from the Ch5 area in the dog were examined using a technique combining horseradish peroxidase (HRP) retrograde labeling with choline acetyltransferase (ChAT) immunocytochemistry. After processing for ChAT, cholinergic neurons were(More)
Utilizing a variation of the Fink-Heimer method, we examined the extent and location of axonal and terminal degeneration within the chicken cervical spinal cord, brainstem and cerebellum resulting from a single subcutaneous dose of bis(1-methylethyl)phosphorofluoridate (DFP). The effects of DFP on the activities of whole-brain neuropathy target esterase(More)
Abou-Donia et al. (in Toxicologist, Vol. 30, 1996) have reported that repeated oral administration of the organo-phosphorus compound triphenyl phosphine (TPPn) to the domestic chicken results in neuropathological changes in the spinal cord and peripheral nerves, accompanied by ataxia and paralysis. This study also noted that single doses of TPPn resulted in(More)
Previous studies in mammals have found that exposure to triphenyl phosphite results in cellular and axonal degeneration in the spinal cord and medulla. However, the nature of concomitant clinical signs suggested that other areas of the central nervous system might also be affected. In this study, the brains of ferrets receiving single subcutaneous(More)
Choline acetyltransferase (ChAT) immunocytochemistry and lectin-conjugated horseradish peroxidase (WGA-HRP) histochemistry were combined at the electron microscopic level to examine the morphology of cholinergic terminals in the canine centrum medianum-parafascicular complex (CM-Pf) and to localize cholinergic terminals making synaptic contact with(More)
Cortical aspirations were made of the dorsomedial prefrontal sector in the rhesus monkey and the resultant anterograde and retrograde degeneration plotted. Retrograde changes were mapped using both cresyl violet and modified Fink-Heimer techniques. Following large dorsomedial lesions, small numbers of degenerating fibers were traced through the medial part(More)
  • D Tanaka
  • The Journal of comparative neurology
  • 1980
The adult and developmental morphology of spiny and aspiny neurons in the dog caudate nucleus was examined using the Golgi-Kopsch technique. In the adult, three types each of spiny and aspiny neurons were identified based upon dendritic morphology and cell soma size. They corresponded in large part to those neurons described previously in the caudate nuclei(More)