Dahai Jiang

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Glutamine can play a critical role in cellular growth in multiple cancers. Glutamine-addicted cancer cells are dependent on glutamine for viability, and their metabolism is reprogrammed for glutamine utilization through the tricarboxylic acid (TCA) cycle. Here, we have uncovered a missing link between cancer invasiveness and glutamine dependence. Using(More)
TP53, a well-known tumour suppressor gene that encodes p53, is frequently inactivated by mutation or deletion in most human tumours. A tremendous effort has been made to restore p53 activity in cancer therapies. However, no effective p53-based therapy has been successfully translated into clinical cancer treatment owing to the complexity of p53 signalling.(More)
  • Sheetal Reginald, D Mello, Aliasger Salem, Satheesh, Elangovan, Maureen Donovan +18 others
  • 2016
D'mello, Sheetal Reginald. "Natural polymer based gene activated matrices for bone regeneration." PhD (Doctor of Philosophy) thesis, ii To my family iii ACKNOWLEDGMENTS When I came to the University of Iowa, I was quite apprehensive about the academic and cultural environment in a big school. And then gradually, I discovered the stimulating, supportive and(More)
Human tumor heterogeneity promotes therapeutic failure by increasing the likelihood of resistant cell subpopulations. The PARP-1 inhibitor olaparib is approved for use in BRCA-mutated ovarian cancers but BRCA2-reversion mutations lead to functional homologous recombination repair (HRR) and olaparib resistance. To overcome that resistance and expand use of(More)
Treatment of chemo-resistant ovarian cancer (OvCa) remains clinically challenging and there is a pressing need to identify novel therapeutic strategies. Here we report that multiple mechanisms that promote OvCa progression and chemo-resistance could be inhibited by ectopic expression of miR-15a and miR-16. Significant correlations between low expression of(More)
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