Dahai Jiang

Anil K. Sood4
Gabriel Lopez-Berestein3
Behnoush Khorsand2
4Anil K. Sood
3Gabriel Lopez-Berestein
2Behnoush Khorsand
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Glutamine can play a critical role in cellular growth in multiple cancers. Glutamine-addicted cancer cells are dependent on glutamine for viability, and their metabolism is reprogrammed for glutamine utilization through the tricarboxylic acid (TCA) cycle. Here, we have uncovered a missing link between cancer invasiveness and glutamine dependence. Using(More)
TP53, a well-known tumour suppressor gene that encodes p53, is frequently inactivated by mutation or deletion in most human tumours. A tremendous effort has been made to restore p53 activity in cancer therapies. However, no effective p53-based therapy has been successfully translated into clinical cancer treatment owing to the complexity of p53 signalling.(More)
  • Amaraporn Wongrakpanich, Aliasger K Salem, Maureen D Donovan, Peter S Thorne, Lewis, L Stevens +29 others
  • 2016
Recommended Citation Wongrakpanich, Amaraporn. "The development of cationic polymers for non-viral gene delivery system." PhD (Doctor of Philosophy) thesis, ii To my parents iii ACKNOWLEDGMENTS My deep gratitude goes first to my advisor, Dr. Aliasger K. Salem for giving me the opportunity to do research in his lab and teaching me how to design and carryout(More)
  • Shailendra Kumar Dhar Dwivedi, Soumyajit Banerjee Mustafi, Lingegowda S. Mangala, Dahai Jiang, Sunila Pradeep, Cristian Rodriguez-Aguayo +7 others
  • 2016
Treatment of chemo-resistant ovarian cancer (OvCa) remains clinically challenging and there is a pressing need to identify novel therapeutic strategies. Here we report that multiple mechanisms that promote OvCa progression and chemo-resistance could be inhibited by ectopic expression of miR-15a and miR-16. Significant correlations between low expression of(More)
  • Sheetal Reginald, D Mello, Aliasger Salem, Satheesh, Elangovan, Maureen Donovan +18 others
  • 2016
D'mello, Sheetal Reginald. "Natural polymer based gene activated matrices for bone regeneration." PhD (Doctor of Philosophy) thesis, ii To my family iii ACKNOWLEDGMENTS When I came to the University of Iowa, I was quite apprehensive about the academic and cultural environment in a big school. And then gradually, I discovered the stimulating, supportive and(More)
  • Dahai Jiang, Jiang, Aliasger K Salem, Mickey Wells, Gary Milavetz, Liu +1 other
  • 2016
Gene therapy and immunotherapy are powerful techniques in the treatment of many life threatening diseases. The major challenge in these therapies is to seek a safe and efficient delivery carrier for gene and antigen materials. Carriers are designed to protect these molecules from degradation, improve their stability and facilitate the delivery of them to(More)
  • Mateusz Rytelewski, Saman Maleki Vareki, Lingegowda S. Mangala, Larissa Romanow, Dahai Jiang, Sunila Pradeep +7 others
  • 2016
Human tumor heterogeneity promotes therapeutic failure by increasing the likelihood of resistant cell subpopulations. The PARP-1 inhibitor olaparib is approved for use in BRCA-mutated ovarian cancers but BRCA2-reversion mutations lead to functional homologous recombination repair (HRR) and olaparib resistance. To overcome that resistance and expand use of(More)
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