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Cardiovascular status in artificially respired whole animal preparations is dependent, among other factors, upon the maintenance of normal blood gas and acid-base equilibria. A method is described for respiring the pithed rat preparation with oxygen-enriched air. Using this system, ventilation-body weight relations have been defined for maintenance of(More)
Angiotensin is known to facilitate the activity of the sympathetic nervous system, and the purpose of the present study was to investigate the possibility that angiotensin converting enzymes (ACE) inhibitors may interfere with neurogenic vasoconstriction by interfering with this interaction between angiotensin and the nervous system. In a pithed rat(More)
1 The purpose of this study was to investigate whether the separation between the hypotensive and sedative effects of a new series of centrally acting antihypertensive drugs was due to differences between the relative pre-junctional (alpha(2)) and post-junctional (alpha(1)) adrenoceptor agonist properties of the compounds.2 In anaesthetized rats the(More)
The effects of captopril and angiotensin II on adrenergic neurotransmission have been studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). In a pithed rat preparation, vasoconstrictor responses evoked by spinal stimulation were greater in SHR than WKY (p less than 0.01). Captopril reduced responses to electrical stimulation and this(More)
Parasites and infectious diseases represent ecological forces shaping animal social evolution. Although empirical studies supporting this link abound in various vertebrate orders, both the study of the dynamics and impact of parasite infections and infectious diseases in strepsirrhine primates have received little empirical attention. We conducted a(More)
Although parasites are important regulatory factors in animal populations, basic knowledge on their fauna in many vertebrate taxa is lacking. In particular, parasite infections of primate species have gained little attention. Here, I present data on the gastro-intestinal fauna of a population of wild red-fronted lemurs ( Eulemur fulvus rufus; Primates:(More)
BACKGROUND Susceptibility to parasite infection affects fitness-related processes, such as mate choice and survival, yet its genetic regulation remains poorly understood. Interleukin-4 (IL4) plays a central role in the humoral immune defence against nematode parasite infections, inducing IgE switch and regulation of worm expulsion from the intestines. The(More)
The present experiments investigate whether the absence of tachycardia during lowering of blood pressure (BP) with an angiotensin-converting enzyme inhibitor (CEI) in salt-depleted dogs is due to an alteration in the activity of the baroreflex. Baroreflex activity was measured after pharmacological manipulation of BP using intravenous nitroglycerin or(More)