Envelope glycoprotein 2 (E2) of hepatitis C virus contains 18 conserved cysteine (Cys) residues in its ectodomain. By cysteine-alanine mutagenesis and function analysis, six Cys in H77 E2 (C494,… (More)
Xiaofang Jia1, Li Liu1, Xiaoqian Liu1, Dage Wu1, Lin Yin1, Xiaohui Liu2, Jiaoli Zhang1, Pengyuan Yang2, Hongzhou Lu1*, and Lijun Zhang1* Shanghai Public Health Clinical Center, Fudan University,… (More)
BACKGROUND
Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), has been widely used in the therapy of human immunodeficiency virus (HIV) infection. Some of its toxic effects on… (More)