Dafydd Rowlands Hughes

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Chronic obstructive pulmonary disease (COPD) is characterized by an abnormal innate immune response. We have investigated the changes in the innate immune response of COPD alveolar macrophages exposed to both cigarette smoke and Toll-like receptor (TLR) stimulation. COPD and control alveolar macrophages were exposed to cigarette smoke extract (CSE) followed(More)
A study of declared psychiatric illness was made over a period of five years in four areas; a rural area, a seaport town and two urban mining valleys. Considerable variation in total rates, sex ratios and age distribution of declared cases between contrasting areas within the catchment area of one psychiatric hospital was found; whereas there was no(More)
Significant cellular sensitivity to peripheral nerve antigens was found by MIF assay in 36% of patients with lung cancer (P<0·005) as compared with 62% of patients with peripheral neuropathy without neoplasia. No sensitivity was found in controls or the cancer sub-group without neuromuscular abnormality. The significance of these findings for an immune(More)
Idiopathic retroperitoneal fibrosis (IRF) is an uncommon disease of obscure etiology and pathobiology. Using sections of frozen and paraffin-embedded tissue, an immunohistochemical technique, and antibodies to a variety of macrophage- and lymphocyte-associated antigens, we studied six examples of IRF. The results showed a large population of spindle-shaped(More)