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Multiplex real-time PCR with quantification of targets in a single fluorescence channel has been the demand in biotechnology industry. Here, we develop a novel analytical real-time PCR technique to detect multiple targets in a single fluorescence channel without melting curve analysis. In this technique, we show the intensity of the fluorescence signals of(More)
Finite mixtures of normal distributions are attractive in identifying the underlying group structure in the data. However, it is a challenging task to do statistical inference in normal mixture models using the method of maximum likelihood, due to the unbounded likelihood and the existence of multiple roots to the likelihood equation including a so-called(More)
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