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Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells.

• Dae-Seop Shin, Hye-Nan Kim, +4 authors B. T. Kwon
• Cancer research
• 2009

Because signal transducer and activator of transcription 3 (STAT3) is constitutively activated in most human solid tumors and is involved in the proliferation, angiogenesis, immune evasion, and… (More)

KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter.

• Young Ju Yoon, Joo Ae Kim, +6 authors Dong Cho Han
• The Journal of biological chemistry
• 2011

Heat shock factor 1 (HSF1) is the master switch for heat shock protein (HSP) expression in eukaryotes. A synthetic chemical library was screened to identify inhibitors of HSF1 using a luciferase… (More)

Blocking tumor cell migration and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic molecule that inhibits Hsp27 phosphorylation.

• Ki Deok Shin, Mi-Young Lee, +6 authors Dong Cho Han
• The Journal of biological chemistry
• 2005

Cell migration is a prerequisite for cancer invasion and metastasis, suggesting cell motility as a potential therapeutic target for cancer treatment. A synthetic library was screened to identify… (More)

Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells.

• Su Hyung Hong, Jina Kim, +6 authors B. T. Kwon
• Biochemical pharmacology
• 2007

2'-Hydroxycinnamaldehyde (HCA), isolated from the stem bark of Cinnamomum cassia, and 2'-benzoyloxycinnamaldehyde (BCA), one of HCA derivatives, have antiproliferative activities on several human… (More)

Predicted drug-induced bradycardia related cardio toxicity using a zebrafish in vivo model is highly correlated with results from in vitro tests.

• Myoung Joo Park, Kyeong-Ryoon Lee, +4 authors Myung Bae
• Toxicology letters
• 2013

Several in vivo and in vitro studies have assessed methods of evaluating the cardio toxicity of compounds during drug development due to its importance for predicting human toxicity. However, in… (More)

Phosphatase of regenerating liver-3 promotes migration and invasion by upregulating matrix metalloproteinases-7 in human colorectal cancer cells.

• Su-Kyung Lee, Y M Han, +8 authors B. T. Kwon
• International journal of cancer
• 2012

Phosphatase of regenerating liver (PRL)-3, a member of a subgroup of protein tyrosine phosphatases that can stimulate the degradation of the extracellular matrix, is over-expressed in metastatic… (More)

Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells.

• Seung-Nam Jung, Dae-Seop Shin, +6 authors B. T. Kwon
• Biochemical pharmacology
• 2015

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in various human cancers and has been used as a therapeutic target for tumors. This study screened natural… (More)

Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway.

• Hyun-mi Kang, Su-Kyung Lee, +5 authors B. T. Kwon
• Life sciences
• 2006

The screening of natural products that preferentially inhibit growth of H-ras transformed rat2 cells vs. rat2 cells was performed to identify H-ras specific growth inhibitor. A lanostane-type… (More)

A novel anti-melanogenic agent, KDZ-001, inhibits tyrosinase enzymatic activity.

• Kyu-Seok Hwang, Jung Yoon Yang, +8 authors Myung Bae
• Journal of dermatological science
• 2018

BACKGROUND The demand for anti-melanogenic agents is increasing due to the unwanted side effects of current treatments. To find an effective anti-melanogenic agent, we used zebrafish as a whole… (More)

Periodic Limb Movements During Sleep is not Associated with Hypertension in a Clinical cohort of Korean Adults.

• Dae-Seop Shin, K Yang, Doh-eui Kim, Young Hwangbo, Brian B. Koo, Yong Won Cho
• American journal of hypertension
• 2018

Background There is growing evidence of increased cardiovascular risk including hypertension in patients with periodic limb movements during sleep (PLMS). In a multiethnic cohort study, the… (More)

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