Dae-Seop Shin

Publications43
h-index15
Citations946
Highly Influential Citations48
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Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells.
TLDR
It is the first report that cryptotanshinone has antitumor activity through the inhibition of STAT3, a potent anticancer agent targeting the activation STAT3 protein.
KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to the hsp70 Promoter*
TLDR
Chromatin immunoprecipitation analysis showed that KRIBB11 inhibited HSF1-dependent recruitment of p-TEFb (positive transcription elongation factor b) to the hsp70 promoter, which strengthens the rationale for targeting HSF 1 in cancer therapy.
Blocking Tumor Cell Migration and Invasion with Biphenyl Isoxazole Derivative KRIBB3, a Synthetic Molecule That Inhibits Hsp27 Phosphorylation*
TLDR
Overall, the results demonstrate that KRIBB3 inhibits tumor cell migration and invasion by blocking protein kinase C-dependent phosphorylation of Hsp27 through its direct binding to HSP27.
Predicted drug-induced bradycardia related cardio toxicity using a zebrafish in vivo model is highly correlated with results from in vitro tests.
Phosphatase of regenerating liver‐3 promotes migration and invasion by upregulating matrix metalloproteinases‐7 in human colorectal cancer cells
TLDR
It was found that PRL‐3 induced MMP‐7 through oncogenic pathways including PI3K/AKT and ERK and that there is a relationship between the expression of PRL-3 and MMP-7 in human tumor cell lines.
Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells.
Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells.
Computational determination of hERG-related cardiotoxicity of drug candidates
TLDR
The neural network model can predict hERG-related cardiotoxicity of chemical compounds with a high accuracy and can be applied to virtual high-throughput screening for drug candidates that do not cause cardiot toxicity.
Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway.
Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents.
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