Dachang Wu

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Human liver was closely associated with gut through various biological mechanisms, such as bacterium–gut interactions. Alterations of gut microbiota seemed to play an important role in induction and promotion of liver damage progression. The aim of this study was to characterize the gut microbiota in liver cirrhosis patients and assess whether there are(More)
Epigallocatechin-3-gallate (EGCG) is a constituent of green tea and has been associated with anticancer activity. In the present study, the inhibitory effect of EGCG on human hepatocellular cancer cells was examined by cell viability assay, in vitro apoptosis assay and cell cycle analysis. In addition, gene expression was measured to elucidate the molecular(More)
Probiotic bacteria are known to exert a wide range of beneficial effects on their animal hosts. Therefore, the present study explored the effect of the supernatants obtained from Lactobacillus delbrueckii fermentation (LBF) on colon cancer. The results indicated that the proliferation of LBF solution-treated colon cancer SW620 cells was arrested and(More)
BACKGROUND The Global Initiative defines COPD for chronic obstructive lung disease as an entirely preventable and treatable disease characterized by sputum production, bacterial colonisation, neutrophilic bronchial airway inflammation and poor health status. The World Health Organization (WHO) estimates that COPD will become the fourth-most common cause of(More)
Pinus massoniana bark proanthocyanidins (PMBPs), an active component isolated from Pinus massoniana bark, has been reported to possess a wide range of biochemical properties. Here, we investigated the anti-tumor effect of PMBPs on ovarian cancer. The results indicated that PMBPs significantly reduced the growth of ovarian cancer cells and induced(More)
UVB (290-320 nm) is one major risk factor of skin diseases in human. In order to provide potential protein molecules in skin cell damage and skin diseases induced by UVB irradiation, the differentially expressed proteins in human keratinocytes cell HaCaT by UVB irradiation were screened by two-dimensional difference in-gel electrophoresis (2D DIGE) combined(More)
Clinicians have long recognized that thyroid hormones have some effects on the gastrointestinal tract. This study aimed to investigate the gut microbiota in hyperthyroid and assess whether there are alterations in the diversity and similarity of gut microbiota in the hyperthyroid when compared with healthy individuals. PCR-denaturing gradient gel(More)
This study was designed to analyse the antioxidant capacity of lactic acid bacteria (LAB) in order to provide characteristic parameters and theoretical basis for its further utilization as a natural antioxidant. Further experiment was carried out to study its protection mechanism through oxidative stress Caco-2 cell model in vitro. For this purpose,(More)
Intestinal probiotic bacterium stimulative activity-guided fractionation of Physalis alkekengi var. Francheti calyces extract resulted in the isolation of four new physalins (1-4). Their structures were elucidated as 5α, 6β-dihydroxy-25, 27-dihydro-7-deoxyphysalin A (1), 5α, 6β-dihydroxyphysalin R (2), 3β-hydroxy-2-hydrophysalin A (3) and(More)
This study aimed to investigate the effects on the intestinal microflora balance of Physalis alkekengi var. francheti extracts (PE) using in vivo mouse model. Luteolin-7-O-β-glycoside, Physalin J, Physalin D, and Physalin P were isolated from PE extracts and identified. Bacteroides, Lactobacillus, Helicobacter, Prevotella, Odoribacter and Oribacterium were(More)