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Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells.
TLDR
It is suggested that AA induced apoptosis through increased intracellular Ca(2+), which, in turn, enhanced p53 expression in HepG2 cells, and further suggest that AA may be a valuable agent for the therapeutic intervention of human hepatomas. Expand
Anti-oxidant and anti-inflammatory activities of macelignan in murine hippocampal cell line and primary culture of rat microglial cells.
TLDR
The results suggest that macelignan possesses therapeutic potentials against neurodegenerative diseases with oxidative stress and neuroinflammation. Expand
Absolute Configurations and NO Inhibitory Activities of Terpenoids from Curcuma longa.
TLDR
The discovery of two new compounds in the ongoing search for inhibitory reagents of NO production and survey of the chemical composition of natural vegetable foods resulted in the isolation of 2 new terpenoids and 14 known analogues, and implied that the natural food spice C. longa, containing terpenoid with NO inhibitory activities, may be potentially promotive to human health. Expand
Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes.
TLDR
The results suggest that asiatic acid and ursolic acid may be an effective inhibitor of UVA-modulated signal transduction pathways in human skin cells and suggest that these agents may be useful in the prevention of U VA-induced photoaging. Expand
Learning strategy selection in the water maze and hippocampal CREB phosphorylation differ in two inbred strains of mice.
TLDR
Findings indicate that pCREB, specifically associated with place/spatial training, is closely tied to differences in spatial/place strategy preference between C57BL/6 and DBA/2 mice. Expand
Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia
TLDR
The results suggest that xanthorrhizol could be an effective candidate for the treatment of Alzheimer's disease‐ and other neurological disease‐related ROS and inflammation. Expand
Cytotoxicity and DNA damage of five organophosphorus pesticides mediated by oxidative stress in PC12 cells and protection by vitamin E
TLDR
Results indicate that oxidative damage is likely to be an initiating event that contributes to the OP-induced cytotoxic and genotoxic effect. Expand
Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats
TLDR
It is demonstrated that oral administrations of macelignan reduce the hippocampal microglial activation induced by chronic infusions of lipopolysaccharide into the fourth ventricle of Fisher-344 rat brains. Expand
Diterpenes inhibiting NO production from Euphorbia helioscopia.
TLDR
Three new jatrophane diterpenes are isolated from the whole plants of Euphorbia helioscopia and showed inhibitory activities on LPS-induced NO production in murine microglial BV-2 cells. Expand
Bioactive Diterpenoids from the Leaves of Callicarpa macrophylla.
TLDR
A phytochemical investigation of the leaves of Callicarpa macrophylla led to the isolation of five new diterpenoids (1-5), macrophypenes A-E, and nine known analogues (6-14) that stimulate nerve growth factor mediated neurite outgrowth from PC12 cells. Expand
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