DV Amrutkar

Learn More
Clinical and genetic studies have suggested a role for voltage gated calcium channels (VGCCs) in the pathogenesis of migraine. Release of calcitonin gene-related peptide (CGRP) from trigeminal neurons has also been implicated in migraine. The VGCCs are located presynaptically on neurons and are involved in the release of these peptides to different stimuli.(More)
Large conductance calcium-activated potassium (BK(Ca)) channels are membrane proteins contributing to electrical propagation through neurons. Calcitonin gene-related peptide (CGRP) is a neuropeptide found in the trigeminovascular system (TGVS). Both BK(Ca) channels and CGRP are involved in migraine pathophysiology. Here we study the expression and(More)
Results GTN infusion in vivo induced a significant mast cell degranulation in a time-dependent manner. Degranulation increased from 30 min (20.3 ±3.0%) to 2 hours (61.0 ±15.3%) reaching a stable level for at least 6 hours (54.5 ±9.3%). In an ex vivo setup, neither of the NO donors GTN (9.65 ±1.17%) or SNP (11.63 ±3.46%) caused mast cell degranulation(More)
BACKGROUND The ATP-sensitive K(+) (K(ATP)) channel openers levcromakalim and pinacidil are vasodilators that induce headache in healthy people. The neuropeptide calcitonin gene-related peptide (CGRP) induces headache in healthy people and migraine in migraineurs, potentially through a mechanism that involves opening of vascular or neuronal K(ATP) channels(More)
  • 1