DONAL MURPHY

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A transfer system that enabled the efficient introduction of transgenes into neurones and the quantitative control of the expressed transgene would greatly facilitate studies into neuronal gene function. To develop such a system we incorporated the tetracycline (Tet)-responsive On/Off regulatory elements into type-5 adenoviral (Ad) vectors. Regulation of(More)
Class 11 MHC molecules (Ia) are transmembrane glycoproteins that function as cell recognition structures during the initiation of an antigen-specific immune response (1). T lymphocytes of the helper-inducer lineage (Th cells) express receptors that recognize foreign antigens in association with the la glycoproteins. The binding of this complex ligand to the(More)
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