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The pattern reversal evoked visual potential (VEP) was recorded in 37 normal subjects and in 186 patients in whom a diagnosis of multiple sclerosis (MS) was established or suspected. Taking the upper limit of normal as the mean +2.5 SD (111 ms), prolonged latency was found in 75% of definite cases of MS, 58% of probable cases, and 38% of possible cases. A(More)
Abnormalities of the potential evoked by stimulation of the median nerve and recorded over the cervical spine were found in 59% of patients with multiple sclerosis (MS) this proportion increasing to 69% of those in the definite diagnosis category and to 100% in the severely disabled. Abnormalities were often found in the absence of relevant clinical signs(More)
OBJECTIVE Stress is associated with an increased intake of palatable foods and with weight gain, particularly in overweight women. Stress, food and body mass index (BMI) have been separately shown to affect amygdala activity. However, it is not known whether stress influences amygdala responses to palatable foods, and whether this response is associated(More)
Pattern reversal visual evoked potentials (VEP) and short-latency somatosensory evoked potentials (SEP) were recorded at frequent intevals in 7 patients with multiple sclerosis (MS). A persistent increase in latency of VEP was found to accompany evanescent visual symptoms. SEP, whether normal or abnormal, remained stable in patients without relapse. In 3(More)
CYP2C19 genotype has been shown to impact response to clopidogrel 75-mg but not prasugrel 10-mg. Here, we assessed effects of CYP2C19 metaboliser status on pharmacokinetics (PK) and pharmacodynamic (PD) responses to prasugrel 5-mg and 10-mg and clopidogrel 75-mg using data from two PK/PD studies in stable coronary artery disease (CAD) patients (GENERATIONS(More)
The records of 1428 neurological patients referred to a department of Clinical Neurophysiology for PRVER testing have been reviewed. Half field studies with multichannel recordings were carried out in the majority. 1186 of these patients had a provisional diagnosis of MS; 42% had abnormal PRVERs compared with 25% for those patients who did not have MS.(More)
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