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The energetics of human muscle have been investigated in vivo during and after fatiguing aerobic, dynamic exercise. Changes in cytoplasmic pH and concentrations of phosphocreatine, ATP and Pi were followed using 31P nuclear magnetic resonance spectroscopy. ATP was significantly depleted in 6 out of 12 experiments and in these 6 experiments decreased to 55(More)
OBJECTIVE Whole brain and regional volume measurement methods were used to quantify white matter, gray matter, and deep gray matter structure volumes in a population of patients with pediatric-onset multiple sclerosis (MS). METHODS Subjects included 38 patients (mean age 15.2 ± 2.4 years) and 33 age- and sex-matched healthy control (HC) participants. MRI(More)
Restricting dietary fat intake while consuming carbohydrates ad libitum has recently been promoted as a weight loss regimen. Sixty subjects (52 females and eight males) were randomized to low fat ad libitum carbohydrate (low-fat) or low fat with caloric restriction (low-calorie) behaviour modification treatments. Forty-nine subjects completed the 16-20 week(More)
To create a behavioral classification of obesity, 2-wk baseline food diaries were obtained from 236 obese women entering weight-loss programs. Subjects monitored food intake along with the social, environmental, and emotional context in which each meal occurred. Variables representing situation-specific eating behaviors were statistically extracted from(More)
Background. Focal cortical dysplasia (FCD) is a frequent cause of medically intractable partial epilepsy of extra-temporal lobe origin. MRI characteristics of focal cortical dysplasia include cortical thickening, poor distinction between gray and white matter transition, and white matter abnormalities such as clusters of abnormal neurons. In many cases, FCD(More)
To facilitate the study of cerebellar degenerative disorders, improved clinical diagnosis is needed. Cerebello-olivary atrophy is pathologically distinct, but until now its diagnosis has been thought to require postmortem examination. This condition was considered as a possible diagnosis in two patients from different families with dominantly inherited(More)
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