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BACKGROUND Dog breeds with the ABCB1-1Δ mutation have substantially truncated nonfunctional P-glycoprotein. Dogs homozygous for this mutation (mut/mut) are susceptible to the toxic adverse effects of ivermectin, loperamide, and vincristine. Anecdotal reports suggested ABCB1 mut/mut dogs showed increased depth and duration of acepromazine sedation. (More)
Elevated blood glucose alone cannot explain the development and progression of diabetic neuropathy (DN) and the lowering of blood glucose is insufficient in preventing and/or reversing neuropathy in patients with type 2 diabetes. Dicarbonyls, such as methylglyoxal (MG), are endogenous by-products of glycolysis, which are elevated in diabetic patients.(More)
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