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Long-term survival of mice infected with Mycobacterium tuberculosis is dependent upon IFN-gamma and T cells, but events in early phases of the immune response are not well understood. In this study, we describe a role for B cells during early immune responses to infection with a clinical isolate of M. tuberculosis (CDC 1551). Following a low-dose infection(More)
N-formylmethionyl (F-Met) peptides, when added alone to macrophages or polymorphonuclear leukocytes (PMN), were found to induce a chemiluminescent response of shorter duration than that produced by the commonly employed particulate stimulant, zymosan. The cellular nature of F-Met peptide-induced chemiluminescence was indicated by its dependence on cell(More)
A modification of Klopf's heterostatic adaptive neuron hypothesis is proposed, in which membrane potential variance, rather than depolarization, has adaptive influence on individual nerve cells. Recordings from each of two configurations of three-cell networks of Aplysia buccal ganglia test for either nonspecific or associative effects of excess membrane(More)
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