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Young (3-week-old) spontaneously hypertensive rats (SHR) had significantly higher basal plasma corticosterone levels than WKY rats and maximum responses to ACTH were also higher. In isolated adrenocortical cells from these rats, corticosterone production was also more responsive to ACTH in SHR. There was no significant difference in aldosterone production.(More)
The neuropathological characteristics of Alzheimer's disease include the selective loss of neurons and the development of senile plaques and neurofibrillary tangles. These plaques and tangles are invariably associated with deposits of an insoluble protein, beta-amyloid, and the hypothesis that the beta-amyloid is responsible for the neuronal loss in(More)
Fibroblasts grown in tissue culture from skin biopsies taken from the genetic model of spontaneously hypertensive rats (SHR), show a reduction in the accumulation of choline when compared to fibroblasts grown from skin biopsies taken from normotensive Wistar Kyoto rats. Choline uptake by fibroblasts from both strains of rats is sodium dependent but there is(More)
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