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The patch-clamp whole cell recording was used to demonstrate activation of membrane conductance to K+, Cl- and cations induced by acetylcholine (ACh) in the isolated acinar cells of the guinea pig nasal gland. A small outward K+ current at 0 mV and a large transient and sustained inward current at -90 mV were evoked by ACh and ACh-evoked reversal potential(More)
By using the whole-cell patch-clamp technique, an amiloride-sensitive Na+-selective conductance was found in epithelial cells from the endolymphatic sac (ES) epithelia of guinea-pigs. In the current-clamp configuration, the average resting membrane potential was -41.7+/-8.4 mV (n = 22). Application of amiloride at a concentration of 20 microM elicited a(More)
Ion currents in epithelial cells isolated from the intermediate portion of endolymphatic sac (ES) in guinea pigs were investigated with the use of the whole cell patch-clamp technique. Depolarizing voltage steps from a holding potential of -60 mV induced a time- and voltage-dependent outward current, which is comparable to that of delayed rectifying K+(More)
Using whole-cell patch-clamp technique and Fura-2 fluorescence measurement, the presence of ATP-activated ion channels and its dependence on intracellular Ca2+ concentration ([Ca2+]i) in the epithelial cells of the endolymphatic sac were investigated. In zero current-clamp configuration, the average resting membrane potential was -66.8+/-1.3 mV (n=18).(More)
Pulmonary sequestration (PS) is an uncommon lung disease. Carcinoid tumorlets in pulmonary sequestration are extremely rare. This case report presents a rare clinical case of carcinoid tumorlet in pulmonary sequestration with bronchiectasis after breast cancer. A 64-year-old female was diagnosed with infiltrating ductal carcinoma of the left breast in(More)
The membrane potential (Em) in epithelial cells isolated from the intermediate portion of the endolymphatic sac (ES) of the guinea-pig was recorded using the whole-cell patch-clamp technique. In the steady state the Em was -53.5+/-1.5 mV (n = 74), which is similar to that in epithelial cells of other tissues. Application of 1 MM ouabain induced a(More)
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