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Wnt signaling mediates self-organization and axis formation in embryoid bodies.
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
These findings provide a previously unrecognized mechanism for receptor recruitment of β-arrestin and demonstrate that Dvl plays an important role in the endocytosis of frizzled, as well as in promoting signaling.
Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development
It is shown how the spatial restriction of Wnt and FGF signals to the limb ectoderm, and to a specialized region of it, the apical ectodermal ridge, controls the distribution of cell behaviors within the growing limb, and guides the proper spatial organization of the differentiating tissues.
Wnt signaling regulates pancreatic β cell proliferation
- I. Rulifson, S. Karnik, Seung K. Kim
- Biology, MedicineProceedings of the National Academy of Sciences
- 10 April 2007
Evidence is provided that Wnt signaling is both necessary and sufficient for islet β cell proliferation, and previously unrecognized evidence of a mechanism governing endocrine pancreas growth and function is provided.
Initiation of Proximal-Distal Patterning in the Vertebrate Limb by Signals and Growth
- Kimberly L. Cooper, J. Hu, D. ten Berge, M. Fernandez‐Teran, M. Ros, C. Tabin
- 27 May 2011
It is demonstrated that early limb mesenchyme in the chick is initially maintained in a state capable of generating all limb segments through exposure to a combination of proximal and distal signals.
Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs.
The results suggest a role for Prx genes in mediating epitheliomesenchymal interactions in inner ear and lower jaw and involve Prx1 and Prx2 in interactions between perichondrium and chondrocytes that regulate their proliferation or differentiation in the bones of the zeugopods.
Endogenous WNT Signals Mediate BMP-Induced and Spontaneous Differentiation of Epiblast Stem Cells and Human Embryonic Stem Cells
Wnt signaling regulates pancreatic beta cell proliferation.
Evidence that Wnt signaling stimulates islet beta cell proliferation is provided, providing previously unrecognized evidence of a mechanism governing endocrine pancreas growth and function.
Wnt signaling mediates regional specification in the vertebrate face
The hypothesis that Wnt signaling is an evolutionarily conserved mechanism controlling facial morphogenesis is tested by determining the pattern of Wnt responsiveness in avian faces, and the consequences of WNT inhibition in the chick face are evaluated.
Bone Regeneration Is Regulated by Wnt Signaling
The role of Wnt signaling in skeletal tissue regeneration is studied to provide a glimpse into normal development as well as insights into pathological conditions such as cancer.